Evaluation of serological diagnostic methods for the 2009 pandemic influenza A (H1N1) virus.
نویسندگان
چکیده
Serology improves influenza diagnosis by capturing cases missed by reverse transcriptase PCR (RT-PCR). We prospectively evaluated microneutralization and hemagglutination inhibition assays for 2009 influenza A (H1N1) virus diagnosis among 24 RT-PCR-confirmed cases and 98 household contacts. Compared to hemagglutination inhibition, microneutralization demonstrated a higher level of concordance with RT-PCR (kappa = 0.69 versus kappa = 0.60) and greater sensitivity (83% versus 71%; P = 0.016).
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ورودعنوان ژورنال:
- Clinical and vaccine immunology : CVI
دوره 18 3 شماره
صفحات -
تاریخ انتشار 2011